MS Analysis Expert

Part I : Everything  You Need to Know About Metabolomics Research Matrix-assisted laser desorption/ionization (MALDI) is a mild ionization method that can obtain intact mass spectrometry  information  of some macromolecular s which  are  easily dissociated into fragments by conventional ionization methods, such as DNA, p roteins, peptides and sugars.   Matrix-assisted laser desorption/ionization (MALDI) is a mild ionization method that can obtain intact mass spectrometry  information of some macromoleculars which are easily dissociated into fragments by conventional ionization methods, such as DNA, proteins, peptides and sugars. Desorption electrospray ionization (DESI) is a direct ionization technique that allows direct analysis of samples under atmospheric conditions with tandem mass spectrometry. The principle is to use a fast moving charged solution stream to extract samples of the contact surface, which can be used for forensic analysis, analysis of drugs, plants, biological

After the protein is translated in the cell, it is processed through a very important step before being transported to the corresponding organelle and undergoing specific biological effects. The role of protein   post-translational modification   ( PTM ) is primarily to alter the activity, localization or function of the protein. Protein PTM  also further increases the diversity and complexity of cellular pathway mechanisms and life activities. Except for acetylation , c ommon protein PTM  include s   phosphorylation , glycosylation , ubiquitination , and the like. Protein  A cetylation  M odification Protein acetylation modification, as the name suggests, refers to the grafting of acetylated groups on the original basis of the protein. In cells, the acetylation modification reaction is catalyzed by an acetyltransferase, and the acetyl group of acetyl-CoA is transferred and added to the protein lysine residue. In earlier studies, acetylation has been considered to be a pos