MS Analysis Expert

In Part I: Recent Advances in Metabolomics Research , we have two advances introduced, “Gut: “Metabnomics” Distinguishes Between Pancreatic Cancer” and “Pancreatitis and Urine Metabolites are Used to Predict the Risk of Diabetes in Individuals”.  Progress in the D evelopment of Single-Neuron Identification Of Chemical Constituents, Physiological Changes, And Metabolism Using Mass Spectrometry by S cientists from University of Science and Technology of China Recently, Proceedings of the National Academy of Sciences of the United States of America (PNAS), the authoritative journal of the National Academy of Sciences published a research paper entitled "Single-Neuron Identification Of Chemical Constituents, Physiological Changes, And Metabolism Using Mass Spectrometry".  T he study relies on electrophysiological patch clamp and electrospray ion source technology to establish stable single neuron intracellular component sampling and mass spectrometry analysis techniques fo...

In terms of  common identification method of a single protein, you may immediately think of Western Blot. Western Blot identifies a target protein by specific binding of the antibody to the target molecule , but this method is suitable for identifying known proteins and must be applied to antibodie s,   and is not suitable for proteins with unknown or without  corresponding antibodies. W hat if the protein to be studied  happens to be  unknown or has no antibody available? In this case, the protein can be identified by means of mass spectrometry. Single P rotein S eparation and P urification When it comes to single protein sample, as the name suggests, this type of protein sample  should have undergone a certain protein purification step to obtain a relatively single protein. Generally, p roteins synthesized by cell lysis or in vitro  contain other heteroproteins, so it is necessary to distinguish the target protein from the heteroprotein. The...

Everything has its dialectics . E ven though we hate high blood fat  as  it hurts our body , lipid  is  an irreplaceable component of  the human body .  Each cell contains phospholipids, whose content is  particularly high in brain, nerves, and liver. They are the most vigorous organs of life. All life activities are affected by lipids.  They regulate cell growth, differentiation, aging, and death . They  are closely related to intelligence and memory . They also affect the development of many diseases including tumors. In the 20th century, with the rapid development of genomics, transcriptomics and proteomics, functional genomics and metabolomics  came into being   in order to fully understand biological phenomena. Lipidomics , originally affiliated with metabolomics,  was f ormally proposed internationally in 2003  as a new independent frontier research field   because of its rapid development .  ...